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Kidney Transplant - Desktop

Transplant

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Kidney Transplant

The first kidney transplant on the African continent was performed in Johannesburg, South Africa, in 1966 – preceding the world’s first heart transplant performed in Cape Town the following year.1

 What was an experimental, risky and very limited treatment option 55 years ago is now a routine clinical practice in more than 80 countries.2 Both living-donor and deceased-donor kidney transplants are possible in South Africa.2

Kidney disease is increasing in South Africa and has become one of the leading causes of mortality, accounting for a staggering 1000 deaths per million population.1 

Kidney transplantation, rather than regular dialysis, is the treatment of choice for patients with end-stage kidney disease.2 This is due to the lower costs and better outcomes associated with transplantation.2

Kidney Transplant

In the last 20 years, the clinical outcomes of kidney transplants have improved as a result of:2

  • Better understanding of the benefits of combined immunosuppressant drugs (to prevent rejection of the donor organ)
  • Improved organ matching 
  • Improved organ preservation
  • Improved treatment of opportunistic infections


Poor adherence to post-transplant immunosuppressive medications can, however, negatively impact long-term outcomes in kidney-transplant patients.3 The rate of non-adherence to these medications in this group ranges between 15% and 55%.3 

Whilst various complex factors play a role in non-adherence with post organ-transplant immunotherapy, cost of the medications is one of the relevant factors.4,5 The advent of generic medications has helped to reduce this cost.4 

Sandoz and Novartis have over 40 years of experience in transplant care and Sandoz is the #1 provider of generic transplant medications in Europe.6 We are proud of our ability to help patients maintain the optimum immunosuppression medication dosing which is so critical to transplant care.6

References
1.

Moosa MR. The State of Kidney Transplantation in South Africa. S Afr Med J. 2019;109(4):235. doi:10.7196/SAMJ.2019.v109i4.13548

2.

Garcia-Garcia G, Chapman J, Harden P. The Global Role of Kidney Transplantation. Indian J Nephrol. 2012;22(2):77. doi:10.4103/0971-4065.97101

3.

Zhu Y, Zhou Y, Zhang L, Zhang J, Lin J. Efficacy of interventions for adherence to the immunosuppressive therapy in kidney transplant recipients: a meta-analysis and systematic review. J Investig Med. 2017;65(7):1049-1056. doi:10.1136/jim-2016-000265

4.

James A, Mannon RB. The Cost of Transplant Immunosuppressant Therapy: Is This Sustainable? Current Transplantation Reports. 2015; 2:113–121.. doi:10.1007/s40472-015-0052-y

5.

Laederach-Hofman K, Bunzel B. Noncompliance in Organ Transplant Recipients: A Literature Review. General Hospital Psychiatry. 2000; 22(6), 412–424. doi:10.1016/s0163-8343(00)00098-0 

6.

Sandoz. News – Media Releases – Sandoz Launches Once-daily Generic Tacrolimus for Transplant Patients in Europe [Online]. Cited 28 Aug 2021. Available from:  https://www.sandoz.com/news/media-releases/sandoz-launches-once-daily-generic-tacrolimus-transplant-patients-europe

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